Successful use of intravenous steroids and pentoxifylline in the treatment of bullous hemorrhagic cellulitis
作者:
MuhartM,
HelfmanT,
KerdelF,
期刊:
Journal of Dermatological Treatment
(Taylor Available online 1996)
卷期:
Volume 7,
issue 3
页码: 193-194
ISSN:0954-6634
年代: 1996
DOI:10.3109/09546639609086887
出版商: Taylor&Francis
关键词: Bullous hemorrhagic cellulitis;IV steroids;pentoxifylline;combination therapy
数据来源: Taylor
摘要:
Bullous hemorrhagic cellulitis is a severe bacterial infection characterized by the rapid development of hemorrhagic bullae, skin necrosis and possible progression to necrotizing fasciitis. It is caused by a number of organisms including group A beta hemolytic streptococcus, gram negatives and anaerobes. The pathogenesis of group A beta hemolytic streptococcal infection, apart from the inherent strain virulence, is felt to be in part due to tumor necrosis factor (TNF) alpha production by the host. We present a case of bullous hemorrhagic cellulitis due to group A beta hemolytic streptococcus successfully treated with the addition of IV steroids and pentoxifylline to the antibiotic regimen. Both corticosteroids and pentoxifylline inhibit TNF alpha activity and its secretion by macrophages.
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