(44–68) human Parathyroid hormone (hPTH) was studied in subretinal fluids (SRF) of 20 human eyes with rhegmatogenous retinal detachments. A (44–68)hPTH carboxyl mid regional radioirnmunoassay was used. Depending on the extent and the duration of the retinal detachments, (44–68)hPTH ranged between normal serum levels (ca. 100–300 pg/ml) up to excessive amounts of 4000 pg/ml with longstanding disease and proliferative vitreoretinopathy.Aqueous humors (AH) of one patient with bilateral iridocyclitis and complicated cataract ranged at 90–132 pg/ml (44–68) hPTH, whereas a control population undergoing surgery for senile cataracts had no detectable (44–68) hPTH in AH. The AH of one diseased eye of heterochromia compli cata Fuchs showed excessive amounts of more than 4000 pg/ml (44–68)hPTH.