Evidence that the Effects of 5-Hydroxytryptophan on the Secretion of ACTH and Growth Hormone in Dogs are not Mediated by Central Release of Serotonin
作者:
H. Zimmermann,
S.L. Kaplan,
W.F. Ganong,
期刊:
Neuroendocrinology
(Karger Available online 1982)
卷期:
Volume 34,
issue 1
页码: 27-31
ISSN:0028-3835
年代: 1982
DOI:10.1159/000123273
出版商: S. Karger AG
关键词: ACTH;Growth hormone;Serotonin;Serotonin-modifying drugs
数据来源: Karger
摘要:
5-Hydroxytryptophan (5-HTP) was found to lower plasma 11-oxycorticoids and increase plasma growth hormone in anesthetized dogs. To determine whether these effects were mediated by release of serotonin, 5-HTP and L-tryptophan were injected intravenously alone and after treatment with various drugs. The decrease in corticoids produced by 5-HTP was unaffected by intravenous carbidopa and metergoline, but was abolished by intravenous benserazide in a dose that inhibits central 5-HTP and dopa decarboxylase, and by a small dose of phenoxybenzamine in the third ventricle. Adrenal sensitivity to ACTH was unaffected by 5-HTP. L-Tryptophan did not decrease plasma corticoids; instead it produced a small increase. The increase in plasma growth hormone produced by 5-HTP was potentiated by carbidopa and abolished by benserazide. L-Tryptophan did not increase plasma growth hormone; instead it produced no change or in some instances a decrease. Plasma growth hormone declined after administration of phenoxybenzamine in the third ventricle, and the decline continued after administration of 5-HTP. The data indicate that the effects of 5-HTP on ACTH and growth hormone secretion are not due to central release of serotonin and suggest that they are due instead to serotonin-induced release of catecholamines from catecholamine-secreting neurons.
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