Four hundred and thirty‐nine Chinese schizophrenic male patients were investigated for the distribution of haptoglobin types; transferrin and group‐specific component subtypes. The allelic frequencies of these three polymorphisms in the patient group were compared with those in healthy controls from published series. An excess ofGc2overGc1(X214.1;P<0.05) as well as a lack ofGclS(X2115.3;P<0.001) was observed in schizophrenia. The relative risks ofGc1F,Gc1SandGc2have been estimated as 1.12, 0.76 and 1.15, respectively. It appears from this study that the presence ofGc2renders individuals susceptible whileGc1Soffers protection for schizophrenia. No such association was found for the haptoglobin or transferrin polymorphi