Unusual Coexistence of Systemic Lupus erythematosus and Primary Biliary Cirrhosis
作者:
F. Nachbar,
H.C. Korting,
R.M. Hoffmann,
M. Kollmann,
M. Meurer,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 4
页码: 313-317
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247174
出版商: S. Karger AG
关键词: Systemic lupus erythematosus;Primary biliary cirrhosis;Overlap syndromes;Antimitochondrial antibodies
数据来源: Karger
摘要:
Systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are distinct clinical disorders which rarely occur in the same patient. We report on a 65-year-old woman with coexistence of both conditions. Diagnosis of SLE was ascertained by the presence of seven ACR criteria (cutaneous lesions, photosensitivity, antinuclear and anti-double-stranded-DNA antibodies, pancytopenia, arthritis, oral lesions). PBC was disclosed by clinical investigation, liver histology and highly positive antimitochondrial M2 antibodies. The most important differential diagnoses of lupus hepatitis are PBC and autoimmune hepatitis. Diagnostic criteria for these conditions are discussed, and previous reports on overlap between SLE and PBC are reviewed.
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