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Detection of 5-(3, 4-Dihydroxy-1, 5-Cyclohexadien-1-Yl) -5-Phenylsydantoin as a Major Metabolite of 5, 5-Diphenylhydantoin (Dilantin) in the Newborn Human

 

作者: M.G. Horning,   C. Stratton,   A. Wilson,   E.C. Horning,   R.M. Hill,  

 

期刊: Analytical Letters  （Taylor Available online 1971）
卷期: Volume 4, issue 8  

页码: 537-545

 

ISSN:0003-2719

 

年代: 1971

 

DOI:10.1080/00032717108058648

 

出版商: Taylor & Francis Group

 

关键词: 5, 5-diphenylhydantoin;gas chromatography;mass spectrometry

 

数据来源: Taylor

 

摘要:

The metabolism of 5, 5-diphenylhydantoin was studied in the newborn human in two instances; one involved direct administration of the drug, and the other was by placental transfer of the drug from the mother. 5-(3,4-Dihydroxy-1, 5-cyclohexadien-1-yl)-5-phenylhydantoin was found to be a major metabolite. The GC and GC-MS methods employed here are well suited to the problem of studying drug metabolism in the newborn.

 

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