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Effects of Fructose-1,6-Diphosphate on the Activity of Rat Liver Nitric Oxide Synthase in vitro

 

作者: Anastasios A. Mihas,   Roy J. Maliakkal,   Thanos A. Mihas,   Vijaya K. Kanji,   Angel K. Markov,  

 

期刊: Pharmacology  （Karger Available online 1997）
卷期: Volume 54, issue 1  

页码: 43-48

 

ISSN:0031-7012

 

年代: 1997

 

DOI:10.1159/000139468

 

出版商: S. Karger AG

 

关键词: Fructose-1,6-diphosphate;Liver;Nitric oxide synthase (NOS)

 

数据来源: Karger

 

摘要:

Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by carbon tetrachloride (CCl4). This finding may have further practical implications in hepatoprotection from various noxious chemical and biological agents.

 

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