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The preparation of ormetoprim labeled with carbon‐14

 

作者: Arnold A. Liebman,   Gerhard J. Bader,   Heinz H. Kaegi,   Clark W. Perry,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1986）
卷期: Volume 23, issue 7  

页码: 693-698

 

ISSN:0362-4803

 

年代: 1986

 

DOI:10.1002/jlcr.2580230703

 

出版商: John Wiley&Sons, Ltd.

 

关键词: 2‐methylveratraldehyde‐7‐14C;ormetoprim‐benzyl‐14C

 

数据来源: WILEY

 

摘要:

AbstractThe sulfonamide potentiator ormetoprim (6) has been prepared with a carbon‐14 label for use in biological studies. The key intermediate. 2‐methylveratraldehyde (4), was prepared by14CO2carbonation of the Grignard reagent from 2‐bromo‐4,5‐dimethoxytoluene (1) followed by esterification. reduction and manganese dioxide

 

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