Role of Kinins in the Acute Antihypertensive Effect of the Converting Enzyme Inhibitor, Captopril
作者:
OSCAR CARRETERO,
SEIJI MIYAZAKI,
ALFONSO SCICLI,
期刊:
Hypertension
(OVID Available online 1981)
卷期:
Volume 3,
issue 1
页码: 18-22
ISSN:0194-911X
年代: 1981
出版商: OVID
关键词: bradykinin;kallikrein;anti-kinin globulins;sodium depletion;kininase II;angiotensin
数据来源: OVID
摘要:
SUMMARY The role of kinins in the acute antihypertensive effect of a converting enzyme inhibitor (CEI) was studied in sodium-depleted normotensive and in two-kidney, one clip chronically hypertensive rats (2K- 1C). The 2K-1C were on a normal sodium diet. The acute vasodepressor effect of the CEI was determined in these two groups either after administration of normal rabbit globulins or antikinin globulins. The amount of kinin antibodies administered completely blocked the hypotensive effects of bradykinin, 400 ng/kg, and urinary kallikrein, 4 $Mg/kg- After administration of CEI in the sodium-depleted rats there was no significant difference (p > 0.05) in the acute changes in mean blood pressure (BP) between the group pretreated with normal rabbit globulins (ABP Δ32.3 ± 3.9 mm Hg) and the group pretreated with antikinin globulins (ABP Δ25 ± 2.5 mm Hg). In the 2K-1C pretreated with normal rabbit globulins, the CEI produced a decrease in BP of −21 ± 4.5 mm Hg. This decrease was almost completely blocked in the group pretreated with the antikinin globulins (ABP Δ4 ± 4.1 mm Hg). These differences in the changes in BP were significant (p< 0.02). These results suggest that the acute antihypertensive effect of the CEI in the sodium-depleted rats is probably due to inhibition of the conversion of angiotensin I to II while in the 2K-1C it is due, in part, to an increase in kinin concentrations secondary to the inhibition of kininase II.
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