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Antiamebic Activity of New Acridinic Derivatives againstNaegleriaandAcanthamoebaSpecies in vitro

 

作者: Antonio Osuna,   Juan Ignacio Rodriguez-Santiago,   Luis-Miguel Ruiz-Perez,   Francisco Gamarro,   Santiago Castanys,   Geneviève Giovannangeli,   Anne-Marie Galy,   Jean-Pierre Galy,   Jean-Claude Soyfer,   Jacques Barbe,  

 

期刊: Chemotherapy  （Karger Available online 1987）
卷期: Volume 33, issue 1  

页码: 18-21

 

ISSN:0009-3157

 

年代: 1987

 

DOI:10.1159/000238471

 

出版商: S. Karger AG

 

关键词: Acridanones;Thioacridanones;Tetrahydrothioacridanones;Iminocridines;Naegleria;Acanthamoeba;Limax amebae chemotherapy

 

数据来源: Karger

 

摘要:

In vitro antiamebic activity of selected acridine derivatives has been investigated against Naegleria and Acanthamoeba species. The most active compounds belong to the 9-thioacridanone and the 1,2,3,4-tetrahydro-9-thioacridanone series. In addition, some structure-activity relationships are proposed.

 

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