Quinolones in Everyday Clinical Practice: Respiratory Tract Infections and Nosocomial Pneumonia
作者:
Günter Marklein,
期刊:
Chemotherapy
(Karger Available online 1996)
卷期:
Volume 42,
issue 1
页码: 33-42
ISSN:0009-3157
年代: 1996
DOI:10.1159/000239490
出版商: S. Karger AG
关键词: Fleroxacin;Ciprofloxacin;Pneumonia;Nosocomial;Community-acquired;Parenteral-oral sequential therapy
数据来源: Karger
摘要:
Currently available fluoroquinolones have established their value in the treatment of lower respiratory tract infections due to gram-negative rods and Staphylococcus aureus. The fact that these drugs are absorbed (and well tolerated) when given orally is a major positive feature. The once daily dosage of fleroxacin [400 mg once daily intravenously (i.v.) for 2-4 days followed by oral doses of 400 mg for up to 10 days] was compared with twice daily ciprofloxacin (400 mg twice daily i.v. for 2-4 days followed by oral doses of 2 x 500 mg for up to 10 days) for treatment of inpatients with pneumonia confirmed by clinical signs and chest X ray. To date, 93 evaluable patients have been enrolled in this study. Clinical cure and improvement rates were 73.3% in the fleroxacin group and 79.2% in the ciprofloxacin group. The rate of adverse clinical or laboratory events was similar in both study groups.
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