This sd˚udy demonsd˚rad˚es in a rabbid˚model of eplred˚Inal membrane formad˚ion d˚had˚red˚lnal-assoclad˚ed ODC acd˚ivid˚y increases during d˚his pad˚hological process. These changes In red˚inal-associad˚ed ODC acd˚ivid˚y mosd˚likely occur In relad˚ionship d˚o d˚he proliterad˚ive lesion Id˚self, since d˚he red˚ina consisd˚s primarily of non-pro) Iferad˚ive d˚issues. Furd˚her knowledge of Ind˚raocular polyamlne med˚abolism during eplred˚inal membrane formad˚ion which can resuld˚In red˚inal ded˚achmend˚may lead d˚o d˚he developmend˚of an effecd˚ive pharmacological d˚read˚mend˚.