Oncogene Expression in Multidrug-Resistant Ovarian Carcinomas
作者:
Lu Jiao,
Lucy Xia,
Mark Horng,
Brandon I. Kashfian,
Mohammed Kashani-Sabet,
Kevin J. Scanlon,
期刊:
Onkologie
(Karger Available online 1996)
卷期:
Volume 19,
issue 1
页码: 19-22
ISSN:0378-584X
年代: 1996
DOI:10.1159/000218882
出版商: S. Karger GmbH
关键词: Cisplatin;Actinomycin D;Multidrug resistance;Oncogenes;p53
数据来源: Karger
摘要:
Proto-oncogenes have been shown to play a critical role in cell growth and differentiation via signal transduction pathways. Oncogenes, either by enhanced gene expression or altered gene expression, can trigger cellular transformation. In this study, the role of oncogenes was defined in drug-resistant human ovarian carcinoma cells. In both multidrug resistant (actinomycin D) cells and non-multidrug-resistant (cisplatin) cells, Northern analyses demonstrated enhanced gene expression for the following oncogenes: c-fos, c-jun, H-ras, and p53. Based on these findings, strategies are discussed for the use of ribozymes, catalytic RNAs, to suppress gene expression and reverse the observed drug resistance.
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