Effects of Oxygen on Wound Responses to Growth Factors: Kaposi's FGF, but not Basic FGF Stimulates Repair in Ischemic Wounds
作者:
WuLiancun,
PierceGlenn F.,
LadinDaniel A.,
ZhaoLily L.,
RogersDavid,
MustoeThomas A.,
期刊:
Growth Factors
(Taylor Available online 1995)
卷期:
Volume 12,
issue 1
页码: 29-35
ISSN:0897-7194
年代: 1995
DOI:10.3109/08977199509003211
出版商: Taylor&Francis
关键词: bFGF;K-FGF;wound healing;ischemia
数据来源: Taylor
摘要:
AbstractKaposi's fibroblast growth factor (K-FGF, FGF-4) is a newer member of FGF family with uncharacterized wound healing properties. Basic fibroblast growth factor (bFGF, FGF-2) has been well studied and accelerates repair in normal and impaired wound healing models. K-FGF and bFGF are known to have similar biological effects in tissue culture, and both stimulate fibroblast and endothelial cell proliferation. The rabbit dermal ulcer model was used to examine the effects of bFGF and K-FGF under ischemic and nonischemic conditions. We found bFGF was ineffective in stimulating healing under ischemic conditions even at high doses (30μg/wound). However, when the ischemic wounds were treated with bFGF (5μg/wound) plus hyperbaric oxygen therapy, it was highly effective again as previously found under nonischemic conditions (P<0.05). In contrast K-FGF stimulated repair in both nonischemic and ischemic wounds (P<0.05). These results suggest that wound oxygen content differentially regulates responsiveness to bFGF and that K-FGF is biologically active in hypoxic wounds.
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