What’s Provoking Different Aggregation between Arterial and Venous Platelets in the Rat?
作者:
Maria Gabriella Doni,
Domenico Bottecchia,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1984)
卷期:
Volume 14,
issue 6
页码: 495-500
ISSN:1424-8832
年代: 1984
DOI:10.1159/000215111
出版商: S. Karger AG
关键词: Platelet aggregation;Arterial and venous PRP;Papaverine;Acetylsalicylic acid;Tranylcypromine;Heart;Lung
数据来源: Karger
摘要:
The present study was designed to clarify the reason why rat platelets obtained from arterial blood show a less marked aggregation than those obtained from venous blood, and to investigate the contribution of the vessel wall to this phenomenon. Incubation of arterial or venous platelet-rich plasma (PRP) with papaverine, a phosphodiesterase blocker, resulted in a more marked inhibition of the aggregation parameters for arterial than for venous PRP, indicating that a cAMP-dependent mechanism is involved. Incubation of PRP in vitro with adenosine deaminase did not significantly modify aggregation. Rats treated in vivo with different doses of acetylsalicylic acid or of tranylcypromine, two cyclo-oxygenase inhibitors, abolished the aggregation differences between arterial and venous PRP. It is suggested that this difference in platelet behavior may be due to a mechanism dependent on a PGl2-like, probably cAMP-related activity in which the heart and/or the lungs may play an important role.
点击下载:
PDF
(1690KB)
返 回