Effects of Dietary Sodium and Genetic Background on Angiotensinogen and Renin in Mouse
作者:
Pierre Lantelme,
Andreas Rohrwasser,
Barbu Gociman,
Elaine Hillas,
Tong Cheng,
Gray Petty,
Jennifer Thomas,
Sha Xiao,
Tomoaki Ishigami,
Tracy Herrmann,
Daniel Terreros,
Kenneth Ward,
Jean-Marc Lalouel,
期刊:
Hypertension: Journal of The American Heart Association
(OVID Available online 2002)
卷期:
Volume 39,
issue 5
页码: 1007-1014
ISSN:0194-911X
年代: 2002
出版商: OVID
关键词: angiotensinogen;renin;sodium;mouse;genetics;urine
数据来源: OVID
摘要:
Elements of a renin-angiotensin system expressed along the entire nephron, including angiotensinogen secreted by proximal tubule and renin expressed in connecting tubule, may participate in the regulation of sodium reabsorption at multiple sites of the nephron. The response of this tubular renin-angiotensin system to stepwise changes in dietary sodium was investigated in 2 mouse strains, the sodium-sensitive inbred C57BL/6 and the sodium-resistant CD1 outbred. Plasma angiotensinogen was not affected by sodium regimen, whereas plasma renin increased 2-fold under low sodium. In both strains, the variation in urinary parameters did not parallel the changes observed in plasma. Angiotensinogen and renin excretion were significantly higher under high sodium than under low sodium. Water deprivation, by contrast, induced significant activation in the tubular expression of angiotensinogen and renin. C57BL/6 exhibited significantly higher urinary excretion of angiotensinogen than did CD1 animals under both conditions of sodium intake. The extent to which these urinary parameters reflect systemic or tubular responses to challenges of sodium homeostasis may depend on the relative contribution of sodium restriction and volume depletion.
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