Interfaces of the Yeast Killer Phenomenon
作者:
PolonelliL.,
ContiS.,
GerloniM.,
MaglianiW.,
ChezziC.,
MoraceG.,
期刊:
Critical Reviews in Microbiology
(Taylor Available online 1991)
卷期:
Volume 18,
issue 1
页码: 47-87
ISSN:1040-841X
年代: 1991
DOI:10.3109/10408419109113509
出版商: Taylor&Francis
关键词: yeast killer toxins;antiidiotypic antibodies;internal imagery;antiidiotypic antibiotics;idiotypic vaccination
数据来源: Taylor
摘要:
AbstractA new prophylactic and therapeutic antimicrobial strategy based on a specific physiological target that is effectively used by killer yeasts in their natural ecological competition is theorized. The natural system exploited is the yeast killer phenomenon previously adopted as an epidemiological marker for intraspecific differentiation of opportunistic yeasts, hyphomycetes, and bacteria. Pathogenic microorganisms(Candida albicans)may be susceptible to the activity of yeast killer toxins due to the presence of specific cell wall receptors. On the basis of the idiotypic network, we report that antiidiotypic antibodies, produced against a monoclonal antibody bearing the receptor-like idiotype, arein vivoprotecting animals immunized through idiotypic vaccination andin vitromimicking the antimicrobial activity of yeast killer toxins, thus acting as antibiotics.
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