Late-phase reaction and tear fluid cytology in the rat ocular anaphylaxis
作者:
BoniniStefano,
TrocmeStefan D.,
BarneyNeal P.,
BrashPeter C.,
BlochKurt J.,
AllansmithMathea R.,
期刊:
Current Eye Research
(Taylor Available online 1987)
卷期:
Volume 6,
issue 5
页码: 659-665
ISSN:0271-3683
年代: 1987
DOI:10.3109/02713688709034828
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Tear fluid cytology is described for the early and late phases of ocular anaphylaxis in actively immunized Sprague-Dawley rats. Tears were collected from both eyes of the rats before challenge and at 1, 2, 4, 6, 8, 10, 12, 24, and 48 h after topical challenge with di-DNP-lysine in one eye and PBS in the fellow eye. Results showed a statistically significant increase in the Aggregate Cell Rating, which represents the aggregate scores in neutrophil, eosinophil, lymphocyte, and atypical epithelial cell levels, in antigen-treated vs control eyes. This report is the first to use a cytologic study of tear film to detect the late phase of ocular anaphylaxis in the rat. Cytology of the tear film could be applied to the study of allergic conjunctivitis in both animals and humans.
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