An 8-year-old girl was infected for a second time withSalmonella typhiby contact with her grandmother, a known typhoid carrier. TheS. typhifrom both patient and grandmother had closely related genomic pulsed field gel electrophoresis patterns that differed from epidemiologically unrelated strains. The girl responded well to a 14-day course of oral trimethoprim-sulfamethoxazole. The grandmother was treated successfully with a 28-day regimen of oral ciprofloxacin. Typhoid fever remains an endemic disease in the United States, largely because of recognized chronic stool carriers. Most of these carriers had typhoid in the preantibiotic ear and remain potential sources of disease when they provide meals for others, not uncommonly grandchildren. The importance of this “grand-mother” connection to endemic typhoid fever is reviewed, as is the potential use of pulsed field gel electrophoresis pattern analysis for comparison of strains ofS. typhi.