Individual Variability of Pathological Parameters in Chemically Induced Rat Colon Tumors
作者:
I. Zusman,
Z. Madar,
A. Nyska,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 145,
issue 2
页码: 106-111
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147350
出版商: S. Karger AG
关键词: Rat colon;N-methyl-N’-nitro-N-nitrosoguanidine;1;2-Dimethylhydrazine;Deoxycholic acid;Precancerous lesions;Mitotic index;Mucopolysaccharides;Tissue polypeptide antigen;Ornithine decarboxylase;Cell tissue damage index
数据来源: Karger
摘要:
The development of tumorigenic conditions in the carcinogen-exposed rat colon was studied using selected morphological, histochemical, immunohistochemical and biochemical methods of analysis. Rats were treated with two carcinogens: 1,2-dimethylhydrazine and N-methyl-N’-nitro-N-nitrosoguanidine alone or with deoxycholic acid as a tumor promoter. It was found that 3 months after treatment of animals with the carcinogens the following changes were developed in colonic tissue: infiltration of lymphocytes in the mucous membrane, high increase in mitotic index among epithelial cells, negative reactions of colonic cells for neutral mucopolysaccharides and sulfomucins and positive reactions to carboxyl groups, nonsulfated acid mucosubstances and tissue polypeptide antigens. An increase in the activity of ornithine decarboxylase in colonic tissue was developed within the same time period and has been seen only in those tissues which were characterized by the development of precancerous conditions. Individual variations were observed in the manifestation of the studied parameters in rat neoplastic colonic tissues. It is suggested that these differences reflect an individual sensitivity of animals to carcinogens and the magnitude of the dysplastic processes induced in the colo
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