Effect of Aging on B‐Cell Function and Replication in Rat Pancreas After 90% Pancreatectomy
作者:
Keiichiro Tanigawa,
Seiji Nakamura,
Mikiko Kawaguchi,
Gang Xu,
Seikon Kin,
Katsuhiro Tamura,
期刊:
Pancreas
(OVID Available online 1997)
卷期:
Volume 15,
issue 1
页码: 53-59
ISSN:0885-3177
年代: 1997
出版商: OVID
关键词: Aging;Islet regeneration;90% pancreatectomy;Diabetes
数据来源: OVID
摘要:
We studied the effect of aging on B-cell function and replication in depancreatized rats. Male Wistar rats, at the ages of 1, 5, and 15 months, underwent 90% pancreatectomy (Px) or a sham operation, and islet function and regeneration were examined 3 weeks later. Plasma glucose levels in 1-month-old rats reached a peak 2 weeks after Px and then declined, while those in 5- and 15-month- old rats reached significant levels as early as the day after Px or 2 days after surgery and continued to increase over the following 3 weeks. Consequently, in contrast to young Px rats, weight loss due to severe diabetes was observed in 5- and 15-month-old Px rats. Plasma glucose responses to intravenous glucose loading (0.5 g/kg body weight) were much greater in older Px rats than in younger rats. There was a marginal insulin response to glucose in 1-month-old Px rats, whereas no insulin response to glucose was observed in older Px animals. The insulin content of the residual pancreas was increased threefold in 1-month-old Px rats, but there was no increase in 5- and 15-month-old Px rats. These data demonstrate that the effect of reducing islet mass is much greater in aged rats than in young rats and that the replicatory capacity of B cells tends to diminish after adulthood has been reached.
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