SPECT Perfusion Imaging in the Diagnosis of Dementia
作者:
William J. Jagust,
Keith A. Johnson,
B. Leonard Holman,
期刊:
Journal of Neuroimaging
(WILEY Available online 2016)
卷期:
Volume 5,
issue s1
页码: 45-52
ISSN:1051-2284
年代: 2016
DOI:10.1111/jon19955s1s45
出版商: Wiley
数据来源: WILEY
摘要:
Single‐photon emission computed tomography (SPECT) imaging has provided the practicing clinician with a method of studying brain function in patients with dementia. A large and growing number of papers report the experiences of a number of laboratories in the use of this technique in the evaluation of demented patients. Studies from several laboratories comparing patients with Alzheimer's disease to control subjects report sensitivity and specificity of SPECT perfusion imaging to be in the 80% vicinity. In addit1on, a number of studies suggest that the dementias that show the greatest similarities in perfusion patterns to Alzheimer's disease are multi‐Infarct dementia and dementia associated with ParkinSon's d1sease. Although considerable data exist to guide the physician, a rigorous scientific approach to studying patients in a prospective, unselected clinical sample, with autopsy confirmation of the diagnosis, is needed to define clearly the utility of the technique in diagnosing dementias.
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