The Role of Culture Media on the Fosfomycin Sensitivity of SixSerratiaStrains and Their Resistant Mutants
作者:
H.B. Drugeon,
A.L. Courtieu,
期刊:
Chemotherapy
(Karger Available online 1982)
卷期:
Volume 28,
issue 5
页码: 345-350
ISSN:0009-3157
年代: 1982
DOI:10.1159/000238102
出版商: S. Karger AG
关键词: Fosfomycin;Antibiotic activity;Minimal inhibitory concentrations;Serratia;Mutation
数据来源: Karger
摘要:
The influence of glucose-6-phosphate (G6P) on the fosfomycin minimum inhibitory concentration (MIC) of six Serratia marcescens strains was determined using two standard media (Müller-Hinton and nutrient agar) and three synthetic media. G6P did not affect fosfomycin MIC when S. marcescens was grown on standard media, but on synthetic media the presence of 5–100 mg/1 G6P lowered the MIC by 1–7 log2. Five fosfomycin-resistant mutants were grown on synthetic media. In the presence of G6P, four of five mutant strains became more sensitive (MICs were 128 mg/1 or less). The fifth mutant strain remained resistant under all culture conditions. The implications of these results are discussed with regard to the mechanism of action of fosfomycin, and the practical determination of the MIC in the cl
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