Antimetabolite interactions with epidermal growth factor
作者:
KopeckyErnest Albert,
RootmanDavid Samuel,
期刊:
Current Eye Research
(Taylor Available online 1996)
卷期:
Volume 15,
issue 3
页码: 247-253
ISSN:0271-3683
年代: 1996
DOI:10.3109/02713689609007618
出版商: Taylor&Francis
关键词: antimetabolites;5-fluorouracil;human epidermal growth factor (hEGF);mitomycin C;corneal wound healing;rabbit
数据来源: Taylor
摘要:
Antimetabolites such as 5-fluorouracil and mitomycin C are known to delay wound healing. Epidermal growth factor (EGF) has been shown to accelerate corneal epithelial wound healing. This study was designed to investigate the effects of EGF on corneal epithelial healing that has been modified by antimetabolite treatment.New Zealand White rabbits were pretreated with either saline (controls) or 5-fluorouracil (5FU) injected subconjunctivally, or mitomycin C (MMC) applied topically. Circular anterior stromal wounds were created, followed by a 6-hour perfusion of normal saline or 50μg/ml of EGF. Subconjunctival saline or 5FU, or topical MMC treatments were continued after wounding for a total of 6 days. Corneas were photographed and quantitative morphometry of the wound site was performed.Compared with saline controls, MMC significantly delayed wound healing (P0.05). Compared with 5FU, MMC significantly delayed wound healing with either normal saline or EGF perfusion (P0.05).Corneal wound healing is not affected by subconjunctivally injected 5FU while it is delayed by topically applied MMC. EGF treatment does not overcome the inhibitory effects of MMC. EGF therapy may not be useful in the treatment of complications related to antimetabolite therapy.
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