Trisomy 7: A potential cytogenetic marker of human prostate cancer progression
作者:
Mark G. Bandyk,
Louis L. Pisters,
Andrew C. Von Eshenbach,
Leland W. K. Chung,
Lian Zhao,
Jan C. Liang,
Patricia Troncoso,
Judy L. Palmer,
期刊:
Genes, Chromosomes and Cancer
(WILEY Available online 1994)
卷期:
Volume 9,
issue 1
页码: 19-27
ISSN:1045-2257
年代: 1994
DOI:10.1002/gcc.2870090105
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractWe used the fluorescence in situ hybridization (FISH) method to show that chromosome 7 trisomy is associated with the progression of human prostate cancer. Thirty‐six specimens including 15 primary prostate carcinomas, 16 metastatic lesions, and 5 normal prostate tissues, as well as 2 prostate carcinoma cell lines of different tumorigenic potential, were examined for chromosome 7 aneuplaidy. Our results showed that the androgen‐unresponsive tumorigenic cell line PC‐3 exhibited a significantly higher ratio of chromosome 7 to total chromosome number than the androgen‐responsive nontumorigenic cell line LNCaP (P = 0.001). In prostate specimens, the frequency of trisomy 7 cells was significantly increased (P<0.05) in the advanced stage tumors (C and D1) but not in the early (6) stage tumors or normal prostatic tissue. Furthermore, metastases showed a higher frequency of trisomy 7 cells than primary tumors (P = 0.005). In 2 patients with paired primary and metastatic tumors, trisomy 7 cells increased from 4‐7% in the primary tumors to 42‐45% in the metastatic tumor cells in the bone marrow. Therefore, our data suggest that trisomy 7 may be a common feature associated with local and metastatic progression and serve as a novel marker for human prostate cancer progression. Genes Chrom Concer 9:/9‐27 (1994). © 1994 W
点击下载:
PDF
(613KB)
返 回