AbstractTreatment of 3‐nitro‐1,6‐naphthyridine, its 2‐chloro‐, 2‐ethoxy‐ and 2‐amino derivatives, with liquid ammonia, containing potassium permanganate, gave the corresponding 2‐X‐4‐amino‐3‐nitro‐1,6‐naphthyridines (X = H, Cl, OEt, NH2). From1H NMR spectroscopy sound evidence for the intermediacy of 2‐X‐4‐amino‐1,4‐dihydro‐3‐nitro‐1,6‐naphthyridine is obtained. Similarly, from 5,8‐dichloro(dibromo)‐1,7‐naphthyridine, the corresponding 2‐amino‐5,8‐dichloro‐(dibromo)‐1,7‐naphthyridines were formed on treatment with liquid ammonia/potassium amide/potassium permanganate.1H