The Maintenance of Normal Parturition in the Rat Requires Neurohypophysial Oxytocin
作者:
S. M. Luckman,
I. Antonijevic,
G. Leng,
S. Dye,
A. J. Douglas,
J. A. Russell,
R. J. Bicknell,
期刊:
Journal of Neuroendocrinology
(WILEY Available online 1993)
卷期:
Volume 5,
issue 1
页码: 7-12
ISSN:0953-8194
年代: 1993
DOI:10.1111/j.1365-2826.1993.tb00358.x
出版商: Blackwell Publishing Ltd
关键词: oxytocin;parturition;morphine;Fos
数据来源: WILEY
摘要:
The neuropeptide oxytocin has long been known as a potent contractor of the uterus. However, it has remained difficult to attribute a definite role for neurohypophysial oxytocin in either the initiation or continuation of labour (1). Most recently, Lefebvre and colleagues (2) have suggested that oxytocin produced in the uterus, rather than in the hypothalamus, may be more important in parturition since at term the uterus of the rat contains 70‐fold more mRNA for oxytocin than the hypothalamus, and this disappears at about the time of parturition. Despite the high levels of mRNA the uterus contains only nanogram quantities of immunoreactive oxytocin per gram wet weight at term (2), compared to microgram quantities present in the pituitary (3,4). Here we show that activation of the neurohypophysial oxytocin system occurs, as reflected by expression of immunoreactivity for Fos in the hypothalamic supraoptic nucleus, and that this activation is indeed critical for normal parturition, since its inhibition results in a significant prolongation of parturition. In addition, we present evidence that pulsatile delivery of oxytocin into the circulation is important for the efficient progress of parturition, indicating that a major role of the neuronal circuits regulating oxytocin secretion for parturition, as is already known for suckling, is to produce an appropriately patterned hormonal output for efficient biological actio
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