The Effect of Erythromycin on the Growth ofRickettsia prowazekiiin the Body Louse (Pediculus humanus corporisL) and the Tick (Ornithodoros moubataMurray)
作者:
Eugeniusz Becla,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 1
页码: 55-61
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221910
出版商: S. Karger AG
关键词: Body lice;Ornithodoros moubataticks;Rickettsiae prowazekii;Erythromycin;Level of erythromycin
数据来源: Karger
摘要:
Body lice (Pediculus humanus corporis L) and ticks (Ornithodoros moubata) that had been infected with Rickettsia prowazekii received varying doses of erythromycin. The anti-rickettsial activity of this drug was evaluated with regard to the determination of the numbers of surviving microorganism (LID100) and the in vivo concentration of erythromycin in both arthropod hosts. Erythromycin was found to exert a rickettsiostatic effect in lice, whereas in ticks the drug at concentrations of 0.3–0.04 μg/mg body weight completely eliminated R. prowazekii
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