Metabolism of Glucose in the Small Intestine of Lean and Obese (ob/ob) Mice
作者:
P.J. Hanson,
A.P. Morton,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1983)
卷期:
Volume 27,
issue 5
页码: 396-403
ISSN:0250-6807
年代: 1983
DOI:10.1159/000176711
出版商: S. Karger AG
关键词: Obese mouse;Glucose metabolism;Small intestine;Hexokinase;Pyruvate kinase;Pentose phosphate pathway
数据来源: Karger
摘要:
The possibility of alterations in the metabolism of glucose in the small intestine of C57BL/6J (ob/ob) obese-diabetic mice has been investigated. Glucose metabolism was assessed by direct measurement in vitro, and by assaying the activities of glycolytic and pentose phosphate pathway enzymes. The small intestine of 3-week-old obese mice exhibited a reduced glucose metabolism and hexokinase activity in comparison with lean controls. In adult animals there was little evidence for an effect of hyperphagia or hyperinsulinaemia on metabolism of glucose supplied from the lumen, except that the elevated pyruvate kinase activity in the intestinal mucosa of 20-week-old obese mice might have been a consequence of hyperinsulinaemia.
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