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Simultaneous Determination of 2-Imidazolines and Other Pharmaceutical Substances in Commercial Preparations by High-Performance Liquid-Chromatography

 

作者: JohnE. Kountourellis,   Antonia Raptouli,  

 

期刊: Analytical Letters  (Taylor Available online 1988)
卷期: Volume 21, issue 8  

页码: 1361-1370

 

ISSN:0003-2719

 

年代: 1988

 

DOI:10.1080/00032718808059869

 

出版商: Taylor & Francis Group

 

关键词: 2-imidazolines;antazoline;tetrahydrozoline;naphazoline;tramazoline;xylometazoline;oxymetazoline;dexamethasone;pharmaceutical formulations;HPLC;alumina

 

数据来源: Taylor

 

摘要:

A rapid HPLC method has been presented for the determination of some 2-imidazolines in several liquid or semi-solid commercial preparations. Two of the active ingredients were determined simultaneously whereas others were determined in the presence of dexamethasone and excipients. From the sample solutions no interference was observed on the chromatograms. Linearity and precision of the method have been assessed. The assay results obtained for various formulations were in accord with the declared amount.

 

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