Prevalence of Microalbuminuria in a Large Population of Patients with Mild to Moderate Essential Hypertension
作者:
Roberto Bigazzi,
Stefano Bianchi,
Vito M. Campese,
Giorgio Baldari,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 61,
issue 1
页码: 94-97
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186842
出版商: S. Karger AG
关键词: Microalbuminuria;Essential hypertension;Renal function
数据来源: Karger
摘要:
To determine the prevalence of increased urinary albumin excretion (UAE) in essential hypertension and to establish whether this abnormality is associated with deranged renal function, we have measured UAE in a group of 123 patients with essential hypertension and in 110 normal subjects. Mean arterial pressure (MAP) was 96 ± 0.6 mm Hg in normal subjects and 121 ± 0.3 mm Hg in patients with essential hypertension (p < 0.01). Mean UAE was 8.6 ± 0.5 in normal subjects and 32.9 ± 3.3 mg/24 h in patients with essential hypertension (p < 0.01). Forty percent of patients with essential hypertension manifested a UAE exceeding 30 mg/24 h and had an average UAE of 72.0 ± 4.7 mg/24 h. MAP in patients with increased UAE was similar to that in subjects with normal UAE (121 ± 0.5 vs. 121 ± 0.4 mm Hg). Creatinine clearance was also not different between these two groups (91 ± 1.8 vs. 94 ± 1.5 ml/min). No correlation was found between UAE and MAP or creatinine clearance. Long-term prospective studies are needed to extablish whether an increase in UAE may predict future nephrosclerosis in essential hype
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