Sleep, Microbes and Cytokines
作者:
James M. Krueger,
Linda A. Toth,
Rachael Floyd,
Jidong Fang,
Levente Kapás,
Sebastian Bredow,
Ferenc Obál, Jr.,
期刊:
Neuroimmunomodulation
(Karger Available online 1994)
卷期:
Volume 1,
issue 2
页码: 100-109
ISSN:1021-7401
年代: 1994
DOI:10.1159/000097142
出版商: S. Karger AG
关键词: Sleep;Infections;Cytokines;EEG;Growth hormone-releasing hormone;Interleukin-1;Muramyl peptides;Endotoxin;Bacteria;Virus;Fever
数据来源: Karger
摘要:
Dynamic changes in sleep in response to infectious challenge are a facet of the acute phase response. Changes in sleep induced by infection seem to be of recuperative value to the host. Furthermore, loss of sleep is associated with changes in immune function. Specific components of microbes such as muramyl peptides or endotoxin from bacteria or double-stranded RNA from virus induce sleep responses. These microbial-induced responses are mediated via enhanced cytokine and hormone production. Interleukin-1, tumor necrosis factor and interferon-αare somnogenic. Interleukin-1-enhanced sleep involves growth hormone-releasing hormone. Microbial-cytokine-altered sleep results from an amplification of physiological sleep mechanisms.
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