ALLOGENEIC BONE MARROW CHIMERISM IN GERM‐FREE MICEIV. THERAPY OF “HODGKIN'S‐LIKE” RETICULUM CELL SARCOMA IN SJL MICE
作者:
ROBERT TRUITT,
MORRIS POLLARD,
期刊:
Transplantation
(OVID Available online 1976)
卷期:
Volume 21,
issue 1
页码: 12-16
ISSN:0041-1337
年代: 1976
出版商: OVID
数据来源: OVID
摘要:
“Hodgkin's-like” reticulum cell sarcoma develops spontaneously in most SJL mice. Germ-free and conventional SJL mice bearing advanced reticulum cell sarcoma were treated with X-irradiation and transplantation of bone marrow from SJL or C3H/He donors. The 120-day survival rate of germ-free mice receiving allogeneic bone marrow (70%) exceeded that of all control groups; more importantly, germ-free mice that survived more than 4 months after treatment with allogeneic cells had no evidence of neoplastic lesions when killed. The germ-free environment effectively prevented graft-versus-host disease that was lethal to conventional mice. The results of these experiments offer additional evidence that bone marrow transplantation can be used as a therapeutic tool for spontaneous murine neoplasms.
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