Nitric Oxide Synthase in Cardiac Nerve Fibers and Neurons of Rat and Guinea Pig Heart
作者:
Lars Klimaschewski,
Wolfgang Kummer,
Bernd Mayer,
Jean Couraud,
Ulrike Preissler,
Bärbel Philippin,
Christine Heym,
期刊:
Circulation Research
(OVID Available online 1992)
卷期:
Volume 71,
issue 6
页码: 1533-1537
ISSN:0009-7330
年代: 1992
出版商: OVID
关键词: nitric oxide;heart;innervation
数据来源: OVID
摘要:
Participation of nitric oxide (NO) in the autonomic innervation of rat and guinea pig hearts was investigated by applying the NADPH diaphorase technique and immunohistochemistry with NO synthase antiserum. We present evidence that NO synthase is localized in cardiac ganglion cells and nerve fibers innervating the sinuatrial and atrioventricular nodes, the myocardium, local neurons, coronary arteries, and pulmonary vessels, suggesting an involvement of NO in neurogenic heart rate regulation, myocardial cell function, neuronal transmission in cardiac ganglia, and coronary as well as pulmonary vasodilation.
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