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Reevaluation of the Pituitary-Adrenal Response to Ether in Rats with Various Cuts Around the Medial Basal Hypothalamus

 

作者: G.B. Makara,   E. Stark,   M. Palkovits,  

 

期刊: Neuroendocrinology  (Karger Available online 1980)
卷期: Volume 30, issue 1  

页码: 38-44

 

ISSN:0028-3835

 

年代: 1980

 

DOI:10.1159/000122972

 

出版商: S. Karger AG

 

关键词: Corticotropin Releasing Factor (CRF);Adrenocorticotropin (ACTH);Corticosterone;Localization;Hypothalamus;Stress response

 

数据来源: Karger

 

摘要:

ACTH release elicited by ether inhalation or ethervenesection and measured by changes in plasma corticosterone level was studied in rats at various time intervals after placing a complete or an anterolateral cut around the medial basal hypothalamus (MBH). There was no rise in ‘resting’ plasma corticosterone after acceptable isolations and, in 5 out of 6 series of experiments, the complete or long anterolateral cuts prevented the rise in plasma corticosterone normally induced by ether stress. In contrast, ethervenesection elicited a significant increment of plasma corticosterone when the basal region of the lateral retrochiasmatic area (RCAL) was not completely transected. Possible reasons why these experiments failed to confirm previous findings are discussed. These results support the hypothesis that corticoliberin-containing fibers enter the MBH from outside and that most of these fibers run through the RCAL on their way towards the neurohemal regions of the infundibu

 

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