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Does bicarbonate therapy improve the management of severe diabetic ketoacidosis?

 

作者: Alain Viallon,   Fabrice Zeni,   Pierre Lafond,   Christophe Venet,   Bernard Tardy,   Yves Page,   Jean-Claude Bertrand,  

 

期刊: Critical Care Medicine  (OVID Available online 1999)
卷期: Volume 27, issue 12  

页码: 2690-2693

 

ISSN:0090-3493

 

年代: 1999

 

出版商: OVID

 

关键词: bicarbonate;diabetic;ketoacidosis

 

数据来源: OVID

 

摘要:

Objective:The use of bicarbonates in the treatment of severe diabetic ketoacidosis remains controversial, especially regarding the benefit/risk ratio. The aim of this study was to assess the efficacy of bicarbonate therapy during severe diabetic ketoacidosis (pH <7.10).Design:Retrospective study.Setting:The emergency unit of a teaching hospital.Patients:The records of 39 patients consecutively admitted for severe diabetic ketoacidosis were analyzed (pH <7.10). The patients were divided into two groups: group 1 (n = 24; patients with bicarbonate treatment) and group 2 (n = 15; patients without bicarbonate treatment).Interventions:None.Measurements and Main Results:We compared two groups of patients presenting with severe diabetic ketoacidosis (pH values between 6.83 and 7.08) treated with or without bicarbonate. A group of 24 patients received 120 ± 40 mmol sodium bicarbonate. The two groups were similar at admission with regard to clinical and biological parameters. No difference could be demonstrated between the two groups concerning the clinical parameters or the normalization time of biochemical parameters. If the number of patients with hypokalemia was comparable between the two groups, the potassium supply was significantly more important in group 1 compared with group 2 (366 ± 74 mmol/L vs. 188 ± 109 mmol/L, respectively;p< .001).Conclusions:Data from the literature and this study are not in favor of the use of bicarbonate in the treatment of diabetic ketoacidosis with pH values between 6.90 and 7.10.

 



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