Effects of Caloric Intake and Dietary Composition on the Development of Proteinuria, Age-Associated Renal Disease and Longevity in the Male Rat
作者:
Arthur V. Everitt,
Barbara D. Porter,
Jennifer R. Wyndham,
期刊:
Gerontology
(Karger Available online 1982)
卷期:
Volume 28,
issue 3
页码: 168-175
ISSN:0304-324X
年代: 1982
DOI:10.1159/000212530
出版商: S. Karger AG
关键词: Male rat;Caloric intake;Dietary protein;Proteinuria;Renal lesions;Kidney weight;Life duration
数据来源: Karger
摘要:
The development of age-associated proteinuria and renal disease was studied in groups of male Wistar rats fed 12.5, 25, 50 and 75 kcal of food/day, respectively, and in calorie-restricted (40 kcal/day) rats receiving diets rich in fat, protein or carbohydrate. Proteinuria developed faster, kidneys were larger and the incidence of glomerular lesions and proteinaceous casts was greater in rats eating high calorie diets of 50 kcal/day or more. High protein diets, even when calorie-restricted, increased protein excretion and the incidence of glomerular lesions. In old rats acute food restriction (25 kcal/day) decreased protein excretion by 40 % in 1 week, with no further reduction in the 2 week. Life duration was greatest in rats fed 50 kcal/day.
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