Glomerulopressin Activity in Carbon Tetrachloride-Induced Cirrhosis in Male Rats
作者:
EliasA. N.,
KhamisehG.,
VaziriN. D.,
期刊:
Renal Failure
(Taylor Available online 1991)
卷期:
Volume 13,
issue 4
页码: 253-257
ISSN:0886-022X
年代: 1991
DOI:10.3109/08860229109022161
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The activity of glomerulopressin, a putative renal vasoregulatory hormone that is synthesized in the liver, was assayed in male rats with carbon tetrachloride-induced cirrhosis and the results were compared to glomerulopressin activity in normal-control and pair-fed animals. Glomerulopressin activity in blood samples collected from the hepatic vein of the cirrhotic group was significantly lower than the activity in the normal-control and pair-fed groups. Glomerulopressin activity in the normal-control and the pair-fed groups were not significantly different. The data support the concept that glomerulopressin deficiency in liver disease, such as cirrhosis, may play a role in the genesis of the functional renal failure associated with liver disease.
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