Ethambutol Neuropathy: Clinical and Electroneuromyographic Studies
作者:
Hiroaki Takeuchi,
Mitsuo Takahashi,
Jin Kang,
Satoshi Ueno,
Seiichiro Tarui,
Yuzo Nakao,
Toshihumi Otori,
期刊:
Psychiatry and Clinical Neurosciences
(WILEY Available online 1980)
卷期:
Volume 34,
issue 1
页码: 45-55
ISSN:1323-1316
年代: 1980
DOI:10.1111/j.1440-1819.1980.tb01512.x
出版商: Blackwell Publishing Ltd
关键词: visual disturbance;ethambutol;neuropathy;toxic;conduction velocity;flicker fusion test
数据来源: WILEY
摘要:
Abstract:Clinical features including changes in the peripheral nerve conduction were analyzed in 10 cases with ethambutol neuropathy. There were abnormalities in the visual field in seven and optic atrophy in five of 10 cases. Seven of 10 cases complained of numbness in the lower limbs. The age of onset and dose of ethambutol the patients continue to take after the occurrence of visual impairment were found to be important in determining the severity of neurological symptoms. A functional disturbance was more conspicuous in ethambutol neuropathy, particularly in the sensory system than in the motor system so far as the peripheral nerve conduction was serially examined. Some cases still had serious optic disturbances even about seven years after the onset of the disease and the presence of irreversible lesions was suspected.
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