Haloperidol potentiates the EEG slowing of MK‐801 despite blocking its motor effectsimplications for the PCP model of schizophrenia
作者:
Irwin Feinberg,
Ian Campbell,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 10
页码: 2189-2193
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: EEG;Glutamate;Haloperidol;NMDA;Period analysis;Receptors;Schizophrenia;Spectral analysis
数据来源: OVID
摘要:
HALOPERIDOL (HP) can block both the motor stimulation and the neurotoxic vacuolization of MK-801, suggesting that the two drugs have antagonistic brain actions. However, we show here that the modest EEG slowing produced by HP and MK-801 individually is massively potentiated when the drugs are combined. This finding challenges the argument for the PCP model of schizophrenia that assumes a general antagonism of neuroleptics and NMDA channel blockers. It further suggests that blockade of MK-801 motor effects is an inadequate test for antipsychotic drug actions. Our data indicate that intact function of D2 receptors (or other HP targets) is required to prevent generalized EEG slowing in the presence of NMDA channel blockade, a possibility of potential clinical interest.
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