Neonatal raphe lesions increase dopamine fibers in prefrontal cortex of adult rats
作者:
Jill Taylor,
Miles Cunningham,
Francine Benes,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1811-1815
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Dopamine;Interactions;Medial prefrontal cortex;Postnatal competition;Serotonin
数据来源: OVID
摘要:
IN order to characterize how the dopamine (DA) and serotonin (5HT) systems may be interacting in medial prefrontal cortex (mPFC) during postnatal development, the specific toxin 5,7-dihydroxytryptamine (5,7-DHT) was used to induce lesions of the nucleus raphe dorsalis (NRD) in neonatal rats and the density of tyrosine hydroxylase-immunoreactive varicosities (TH-IRv) was assessed. During the early adult period, lesioned rats showed a significant increase in the density of the THIR fibers in layers V and VI when compared with sham-treated animals. These results suggest that postnatal development in medial prefrontal cortex may be associated with a competitive interaction between cortical monoaminergic systems, such that an early disturbance in the development of the 5HT innervation can potentially induce a hyperinnervation of DA fibres.
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