Improvement of Motor Fluctuations in Patients with Parkinson’s Disease Following Treatment with High Doses of Pergolide and Cessation of Levodopa
作者:
Johannes Schwarz,
Klaus Scheidtmann,
Claudia Trenkwalder,
期刊:
European Neurology
(Karger Available online 1997)
卷期:
Volume 37,
issue 4
页码: 236-238
ISSN:0014-3022
年代: 1997
DOI:10.1159/000117449
出版商: S. Karger AG
关键词: Parkinson’s disease;Motor fluctuations;Dopamine agonist;Pergolide;Levodopa
数据来源: Karger
摘要:
The combination of levodopa and a dopamine agonist in the treatment of patients with Parkinson’s disease often reduces the severity of motor fluctuations. In patients with very severe motor fluctuations, monotherapy with continuous subcutaneous infusions of the dopamine agonist apomorphine may result in a marked reduction of hyperkinesia and on-off phenomena. We report 3 patients with Parkinson’s disease and motor fluctuations who received high doses of pergolide without levodopa resulting in a reduction of motor fluctuations. All patients received doses of pergolide exceeding the maximum recommended dose. One patient also required additional therapy with amantadine. These data show that in some patients oral treatment with high doses of a dopamine agonist may improve the severity of motor fluctuations and achieve a good control of parkinsonian signs without concomitant levodopa treatm
点击下载:
PDF
(710KB)
返 回