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Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
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Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
作者:
Hugo Costa-Ribeiro,
Tereza Cristina Ribeiro,
Angela Mattos,
Sandra Valois,
Daniela Neri,
Patricia Almeida,
Celina Cerqueira,
Eduardo Ramos,
Rosemary Young,
Jon Vanderhoof,
期刊:
Journal of Pediatric Gastroenterology and Nutrition
(OVID Available online 2003)
卷期:
Volume 36,
issue 1
页码: 112-115
ISSN:0277-2116
年代: 2003
出版商: OVID
数据来源: OVID
摘要:
BackgroundRecent studies have shown that probiotics, most commonlyLactobacillus GG, may be useful in treating acute gastroenteritis. However, beneficial effects appear to be limited to a modest decrease in the duration of diarrhea. No studies have evaluated this therapy in moderate to severe dehydrating diarrhea in a metabolic facility.MethodsMale children less than 2 years of age were admitted to a metabolic unit of the Department of Pediatrics at the Federal University of Bahia, Brazil, with moderate dehydration and were randomized in a double-blind, placebo-controlled fashion. Oral rehydration solution (ORS) was administered per protocol and either placebo orLactobacillus GGwas given in combination with the ORS. Output of urine, stool, and vomitus was recorded along with stool weight, nude body weight, and standard laboratory assessments for hydration.ResultsThere was no significant reduction in diarrhea duration and stool output in theLactobacillus GGgroup. However, Kaplan-Meier survival analysis demonstrated that, even in moderate to severe diarrhea, resolution of the illness occurred so rapidly, that statistically significant benefits of probiotic therapy could not be demonstrated.ConclusionOur data implies that colonization must occur before benefits of probiotics can be realized. Probiotics are, therefore, likely to be of limited benefit in treating diarrheal illnesses of short duration such as viral enteritis. The beneficial effects of probiotics may be limited to prophylactic usage in high-risk populations.
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