Toxicological Aspects of Topical Silver Pharmaceuticals
作者:
HollingerMannfred A.,
期刊:
Critical Reviews in Toxicology
(Taylor Available online 1996)
卷期:
Volume 26,
issue 3
页码: 255-260
ISSN:1040-8444
年代: 1996
DOI:10.3109/10408449609012524
出版商: Taylor&Francis
关键词: silver;toxicity;wound healing;iontophoresis
数据来源: Taylor
摘要:
AbstractSilver is generally considered to present a relatively low toxic threat to humans because unintentional exposure to large doses of the noble metal is quite rare. However, as the intentional utilization of silver in pharmaceutical preparations and devices increases, subtle toxic effects of silver may be predictable and expected. The present review examines the scientific literature, primarily covering the past 10 years, dealing with reports describing various types of silver toxicity. These reports consist of bothin vitroandin vivodata dealing with immunological, mesenchymal, neural, and parenchymal cell types. Particular emphasis is given to (1) the use of silver in topical antimicrobial preparations as toxicity relates to absorption through dermal wounds into the systemic circulation and possible effects on delayed wound healing, (2) possible local silver toxicity via iontophoretic devices, (3) current theories relating to the toxicological mechanism of action of silver.
点击下载:
PDF (506KB)
返 回