Amplification of the Epidermal Growth Factor Receptor Gene in Biopsy Specimens from Human Intracranial Tumours
作者:
HelsethEirik,
UnsgaardGeirmund,
DalenAre,
FureHilde,
SkandsenToril,
ØdegaardArne,
VikRandi,
期刊:
British Journal of Neurosurgery
(Taylor Available online 1988)
卷期:
Volume 2,
issue 2
页码: 217-225
ISSN:0268-8697
年代: 1988
DOI:10.3109/02688698808992672
出版商: Taylor&Francis
关键词: Proto-oncogene amplification and intracranial tumours;epidermal growth factor receptor
数据来源: Taylor
摘要:
Amplification and overexpression of proto-oncogenes are associated with the malignant nature of some human tumours. In this study we have determined the prevalence of amplification of the proto-oncogenes c-erb Bl (= epidermal growth factor receptor gene), c-erb B2 and c-myc in 44 human intracranial tumours (27 gliomas, six metastases to the brain and 11 meningiomas). None of the tumours had an amplified c-erb B2 gene and only two tumours had an amplified c-myc gene. Nineteen per cent (five out of 27) of the gliomas, 50% (three out of six) of the brain metastases and 0% (0 out of 11) meningiomas had an amplified EGF-receptor gene. Amplification of the EGF-receptor gene appeared to give a growth advantage when single-cell suspensions of the tumours were grown in agarose.
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