Evidence for Altered Desipramine Disposition in Methadone-Maintained Patients Treated for Cocaine Abuse
作者:
KostenThomas R.,
GawinFrank H.,
MorganCharles,
NelsonJ. Craig,
JatlowPeter,
期刊:
The American Journal of Drug and Alcohol Abuse
(Taylor Available online 1990)
卷期:
Volume 16,
issue 3-4
页码: 329-336
ISSN:0095-2990
年代: 1990
DOI:10.3109/00952999009001594
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Plasma concentrations of desipramine (DMI) and its 2-hydroxy metabolite (OHDMI) were compared among 72 patients being treated with desipramine for either depression (n = 39) or cocaine abuse(n= 33). Eleven cocaine abusers who were concurrently maintained on methadone had a significantly lower ratio of DMI dose to plasma concentration (0.9) than the depressives (2.2) or nonmethadone cocaine abusers (2.0). Their OHDMI/DMI ratios were significantly lower (0.19) than for either the other 22 cocaine abusers (0.39) or the depressed (0.50) patients. This difference was not due to DMI dosage. Although the underlying mechanism cannot be determined from these plasma studies, possible reduced hydroxylation of DMI in methadone patients suggests the need for DMI plasma monitoring.
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