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Does a Centralized Clock for Ageing Exist?

 

作者: P.E. Kloeden,   R. Rössler,   O.E. Rössler,  

 

期刊: Gerontology  (Karger Available online 1990)
卷期: Volume 36, issue 5-6  

页码: 314-322

 

ISSN:0304-324X

 

年代: 1990

 

DOI:10.1159/000213216

 

出版商: S. Karger AG

 

关键词: Life expectancy curves;Programmed theory of ageing;Zeitgeber;Pineal calcification;Melatonin fluctuations;Experimental verification

 

数据来源: Karger

 

摘要:

It is proposed that a centralized clock controlling ageing is located in the pineal gland with the calcification process occurring there providing a highly accurate bio-inorganic timing mechanism and the secreted melatonin carrying a signal to all cells in the organism. An explicit programme of data gathering and experiments suitable for the falsification of the proposal, which is consistent with presently known anatomical and physiological facts, is presented. The underlying motivation comes from evolutionary biology and the invariance, that is the allometry, of life expectancy curves.

 

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