AbstractA summary is presented of the chemical reactivity evaluation aspects of the soon to be published “Guidelines for Chemical Reactivity Evaluation and Application to Process Design” developed under the sponsorship of the Center for Chemical Process Safety. Emphasis is placed on strategies for thermochemical evaluation of industrial chemical substances.Certain structural entities, for example, high degrees of unsaturation and nitrogenhalogen linkages, will likely identify hazardous reactive chemicals. The effects of impurities in the chemicals, as well as, for example, incidental contact with water and air (oxygen), must also be considered in the evluation of potential reactivity hazards, representing undesired reactions.Various test methods are indicated briefly along with the rationale for use of specific methods in hazard evaluat