Use of X-Linked Clonal Analysis in Acute Promyelocytic Leukemia
作者:
TaylorKerry McD.,
RodwellRobyn L.,
ElliottSuzanne L.,
TaylorDebra L.,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 11,
issue 5-6
页码: 339-343
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309067924
出版商: Taylor&Francis
关键词: Clonality;X-linked clonal analysis;retinoic acid;differentiation
数据来源: Taylor
摘要:
X-linked clonal analysis (XLCA) either using Glucose-6-phosphate dehydrogenase (G-6-P-D) polymorphisms or restriction fragment length polymorphisms (RFLP) and methylation analysts has provided considerable understanding of haematologic malignancy. Acute Promyelocytic Leukemia (APL) is characterized by a unique cytogenetic translocation t(15;17), frequent achievement of remission without a preceding phase of marrow hypocellularity after induction chemotherapy and a high rate of clinical response to all-trans retinoic acid (ATRA). In limited studies XLCA has provided insight into the pathogenesis and mechanism of drug action in this disease.
点击下载:
PDF (467KB)
返 回