Retinoblastoma: Messenger RNA for interphotoreceptor retinoid binding protein
作者:
RodriguesMerlyn M.,
RajagopalanSankaran,
LeeLing,
NairC. N.,
AdvaniS. H.,
DonosoLarry,
ChaderGerald J.,
WiggertBarbara,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue 5
页码: 425-433
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689209001796
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Histopathology revealed mostly poorly differentiated tumors with necrosis and lack of Flexner-Wintersteiner rosettes. Immunocytochemical staining showed focal IRBP expression in one of the tumors and S-antigen in two cases. Immunoreactivity with rhodopsin was negative. N-CAM, a neural adhesive protein which appears to be involved in the regulation of adhesive interaction during neuronal differentiation, was positive except in two cases. All tumors showed immunoreactivity with NSE, whereas GFAP staining was limited to the perivascular glial tissue confirming the essential neuronal nature of retinoblastoma cells. Tc was detected in all tumors and TRαin one case. Messenger RNA for IRBP was detected in tumors in which IRBP immunoreactivity could not be detected.
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